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Elucidating Mechanisms of Cell Competition During Development

Description: Project Narrative Due to evolution, numerous genes exist in very similar forms in other organisms, such as the fruit fly Drosophila. The fruit fly is an excellent genetic organism that has been used with great success to identify and characterize genes critical for basic biological processes. Our study is designed to eludicate how the conserved genes that cause cancer in humans regulate cell competition in Drosophila.
Funding type: research
Funder scheme: R01
Start date: 2009-02-01
End date: 2025-08-31
Investigator: ERIKA A BACH
Institution: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Funded outputs count: 41
Funder award ID: R01GM085075
OpenAlex ID: G716156348
Protocol for high-sensitivity detection of microRNAs in adult Drosophila tissues using hybridization chain reaction
2026 · Sneh Harsh, Amelie A. Raz, et al. · STAR Protocols
Age-related decline in niche self-renewal factors drives testis aging via Hairless, Imp, and Chinmo
2026 · Pin-Kuan Chiang, Ya-Chien Lee, et al. · Science Advances · 2
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
2025 · Sneh Harsh, Hsiao-Yun Liu, et al. · PLoS Biology · 4
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Sex-converted testis somatic cells acquire female-specific behaviors and alter XY germline identity
2025 · Tiffany V. Roach, Sneh Harsh, et al. · Development · 2
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Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo
2025 · Yu Zheng, Ya-Chien Lee, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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The pioneer factor Zelda induces male-to-female somatic sex reversal in adult tissues
2025 · Sneh Harsh, Hsiao-Yun Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Mechanisms of Germline Stem Cell Competition across Species
2024 · Rachel A. Hodge, Erika A. Bach · Life · 3
Spermatogonial Dedifferentiation into Germline Stem Cells in Drosophila Testes
2023 · Salvador C. Herrera, Erika A. Bach · Methods in molecular biology · 1
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chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche
2021 · Chen-Yuan Tseng, Michael Burel, et al. · Developmental Cell · 27
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin
2021 · Salvador C. Herrera, Diego Sainz de la Maza, et al. · Developmental Cell · 37
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The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis
2021 · Salvador C. Herrera, Erika A. Bach · International Journal of Molecular Sciences · 39
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Transcriptomic analysis of feminizing somatic stem cells in theDrosophilatestis reveals putative downstream effectors of the transcription factor Chinmo
2021 · Lydia Grmai, Sneh Harsh, et al. · G3 Genes Genomes Genetics · 9
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Next-Generation Sequencing Reveals Increased Anti-oxidant Response and Ecdysone Signaling in STAT Supercompetitors in Drosophila
2019 · Poojitha Sitaram, Sean Lu, et al. · G3 Genes Genomes Genetics · 5
Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity
2019 · Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, et al. · Disease Models & Mechanisms · 14
JAK/STAT signaling in stem cells and regeneration: fromDrosophilato vertebrates
2019 · Salvador C. Herrera, Erika A. Bach · Development · 212
JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the Drosophila testis
2018 · Salvador C Herrera, Erika A Bach · eLife · 46
Chinmo prevents transformer alternative splicing to maintain male sex identity
2018 · Lydia Grmai, Bruno Hudry, et al. · PLoS Genetics · 41
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A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies inDrosophila melanogaster
2017 · Abigail M Anderson, Alessandro A Bailetti, et al. · G3 Genes Genomes Genetics · 23
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Neutral Competition forDrosophilaFollicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes
2017 · Matthew S Cook, Coralie Cazin, et al. · Genetics · 15
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Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
2016 · Marc Amoyel, Kenzo-Hugo Hillion, et al. · Development · 58
Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis
2016 · Marc Amoyel, Jason Anderson, et al. · PLoS Genetics · 65
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MT-Nanotubes: Lifelines for Stem Cells
2015 · Marc Amoyel, Erika A. Bach · Cell stem cell · 1
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Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo
2014 · Marc Amoyel, Benjamin D Simons, et al. · The EMBO Journal · 99
JAK/STAT pathway dysregulation in tumors: A Drosophila perspective
2014 · Marc Amoyel, Abigail M. Anderson, et al. · Seminars in Cell and Developmental Biology · 91
Cell competition: how to eliminate your neighbours
2014 · Marc Amoyel, Erika A. Bach · Development · 201
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