Physiological and molecular mechanisms underlying renal congestion in congestive heart failure
Description: We created a rat renal congestion model and investigated the effect of renal congestion on hemodynamics and molecular mechanisms. Tubulointerstitial injury and medullary thick ascending limb hypoxia were observed only in the congestive kidneys. Using this rat congestion model and cell culture system, we revealed that vacuolar ATPase system in acidic organelles and pericyte injury were involved in the development of renal interstitial fibrosis due to renal congestion.
Amount: ¥17,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Takefumi MORI
Institution: Tohoku Medical and Pharmaceutical University
Funded outputs count: 7
Funder award ID: 16H05312
OpenAlex ID: G2698346017