Mediators of Muscle Rejuvenation with Aging
Description: Project Narrative Exercise is a powerful stimulus for attenuating age-associated tissue decline, but the molecular mechanisms behind this are incompletely understood. Using muscle functional, bioenergetic, and cellular measures as well as nucleus-specific DNA methylation aging analysis and single myonuclear RNA-sequencing, the purpose of this proposal is to provide fundamental information on what mediates skeletal muscle molecular reprogramming toward youthfulness. Combined with a conditional and inducible muscle-specific gene expression model and a new murine exercise training approach, we hypothesize that the exercise-responsive Yamanaka factor MYC plays a central role in promoting a youthful tissue profile during aging and can be leveraged to improve muscle health throughout the lifespan.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2023-08-01
End date: 2028-04-30
Investigator: KEVIN MURACH
Institution: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
Funded outputs count: 29
Funder award ID: R01AG080047
OpenAlex ID: G9000869988