Mechanisms and impact of osteoblast "citration" on skeletal mineralization and global citrate homeostasis
Description: PROJECT NARRATIVE Citrate is used by all aerobic organisms to produce usable chemical energy and is present in mineralized tissues (bone and teeth) at strikingly high concentrations. In this project, we will determine the mechanisms responsible for mineral citrate deposition in mice and men and the consequences of altered citrate handling by the osteoblast on tissue mineralization, citricemia and citruria, provoked by genetic mutations, pharmacologic interventions or in responds to endocrine cues. We believe our studies will validate a new metabolic pathway linking citrate metabolism to the biomechanical and physiological functions of mineralized tissues with the osteoblast as a central player.
Funding type: career_development
Funder scheme: K99
Start date: 2022-09-01
End date: 2024-08-31
Investigator: NAOMI DIRCKX (lead)
Institutions: University of Maryland, Baltimore, UNIVERSITY OF MARYLAND BALTIMORE
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Funded outputs count: 3
Funder award ID: K99AR079558
OpenAlex ID: G6087358095