Age-equivalent neurons from MCI patients to investigate early determinants of AD
Description: NARRATIVE The project by Dr. Mertens and colleagues aims at deciphering the interface of age-related pathways and genetic risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD) using patient-specific induced neurons (iNs). The team will study the underlying molecular structures of MCI using unbiased multi-omic approaches in MCI and AD patient-derived iNs, and compare them to healthily aging control iNs. They will further employ targeted experiments to study the role of neuronal functionality as a convergence platform for aging and disease, and they will leverage insights from their multi-layered characterizations to explore novel approaches to treat MCI and AD.
Funder: National Institutes of Health
Amount: $793,700
Funding type: research
Funder scheme: R01
Start date: 2024-08-15
End date: 2029-04-30
Investigator: JEROME S. MERTENS
Institution: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Funded outputs count: 5
Funder award ID: 1r01ag085634-01a1
OpenAlex ID: G2729066994