Analysis of relationship between beta amyloid accumulation and autophagic pathway
Description: It had previously reported that loss of autophagy was involved in neurodegeneration even in the absence of any mutant proteins. Therefore, it was predicted that autophagy function is lost or attenuated in AD, and intraneuronal accumulation of Aβ could induce dysfunction of autophagy in AD transgenic mouse brain with aging. Employing Tg2576 mouse we observed intraneuronal expression of Beclin 1, autophagic protein, with aging. However, the reduction of intraneuronal Beclin 1 was not observed in Tg2576 mouse brain tissue by immunohistochemical labelling. In contrast, remarkable reduction of intraneuronal Beclin 1 was observed in brain tissue from patients with dementia. These results might be able to conclude that human brain tissue is more available to investigate intraneuronal autophagic dysfunction than mouse tissue.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2023-03-31
Investigator: Reisuke Takahashi
Institution: Tokyo Medical University
Funded outputs count: 4
Funder award ID: 17K08524
OpenAlex ID: G2731320570