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Study of Muscle, Mobility and Aging: SOMMA2

Description: SOMMA is a groundbreaking, highly productive and impactful study about the biological basis of mobility. SOMMA2 expands the cohort, adding power to test new hypotheses that pathways, such as DNA damage, play a role in disability, dementia and death and in the decline of muscle power and fitness with aging.
Funding type: research
Funder scheme: R01
Start date: 2018-06-15
End date: 2029-06-30
Investigator: STEVEN RON CUMMINGS
Institution: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
Funded outputs count: 75
Funder award ID: R01AG059416
OpenAlex ID: G9000880550
Advancing aging biomarkers and intervention discovery at the TimePie Longevity Forum
2026 · Kejun Ying, Juntao Bie, et al. · Nature Aging
Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging
2026 · Daniel S. Evans, Tyler A. Mansfield, et al. · Arthritis & Rheumatology
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Energetic pathway to lower urinary tract symptoms in older adults: associations with cardiorespiratory fitness and walking energetics in the study of muscle, mobility and aging
2026 · Ferdinand Anokwuru, Tyler A. Mansfield, et al. · GeroScience
Greater D3-creatine muscle mass and MRI thigh muscle volume are associated with higher bone strength in older adults: exploratory findings in The Study of Muscle, Mobility and Aging (SOMMA)
2026 · Nina Z Heilmann, Kerri S Freeland, et al. · JBMR Plus
A Bayesian network analysis of gait speed change upon transition to uneven surfaces in older adults
2026 · Yixiao Song, Caterina Rosano, et al. · The Journals of Gerontology Series A
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Sex- and site-specific associations between hemoglobin levels and cortical bone structure and microarchitecture in older adults
2026 · Nicole M. Sekel, Mita Lovalekar, et al. · Bone
HR-pQCT skeletal phenotype clustering associated with muscle function in older men and women: the Study of Muscle, Mobility and Aging (SOMMA)
2026 · Morgan W Bolger, Kerri S Freeland, et al. · Journal of Bone and Mineral Research · 1
Greater recalled pain and movement-evoked pain are associated with longer 400-m walk and repeat stair climb timein older adults: the study of muscle, mobility, and aging
2026 · Theresa Mau, Corey B. Simon, et al. · GeroScience
Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)
2026 · Daniel S. Evans, Tyler A. Mansfield, et al. · medRxiv · 1
Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging
2026 · Namki Hong, Sang Wouk Cho, et al. · Aging Cell · 2
Striatal dopamine and skeletal muscle energy metabolism in older adults
2026 · Caterina Rosano, Nico I Bohnen, et al. · The Journals of Gerontology Series A · 2
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MicroRNA Regulatory Targets Related to VO 2 peak Decline in Older Adult Participants of the Study of Muscle, Mobility and Aging (SOMMA)
2026 · Genesio M. Karere, Fang-Chi Hsu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Single‐Nuclei Resolution of Intermuscular Adipose Tissue Indicates an Inflammation‐Associated Cellular Profile in Individuals With Knee Osteoarthritis: Findings From the SOMMA KOA Ancillary Study
2025 · Line O. Elingaard‐Larsen, Katie L. Whytock, et al. · Aging Cell · 1
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Circadian physiology changes with aging: age is just a number, but circadian physiology keeps time
2025 · Natalie J Bohmke, Karyn A Esser · Current Opinion in Physiology
MicroRNA signatures of cardiorespiratory fitness (VO2peak) in older adults: Insights from the study of muscle, mobility, and aging
2025 · Genesio M Karere, Fang-Chi Hsu, et al. · The Journals of Gerontology Series A
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Nigrostriatal dopaminergic integrity in relation to prefrontal cortex activity and gait performance during dual-task walking in older adults
2025 · Andrea L Rosso, Emma M Baillargeon, et al. · The Journals of Gerontology Series A · 3
Power and Endurance: Polar Opposites or Willing Partners?
2025 · CARRIE FERGUSON, REGULA FURRER, et al. · Medicine & Science in Sports & Exercise · 5
Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults
2025 · Emma L. Gay, Caterina Rosano, et al. · Aging Cell · 1
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Association of cardiorespiratory fitness with HR-pQCT bone parameters in older adults: the Study of Muscle, Mobility and Aging (SOMMA)
2025 · Nina Z. Heilmann, Kerri S. Freeland, et al. · Osteoporosis International · 4
Subcutaneous Adipose Tissue-Secreted Proteins as Endocrine Regulators of Physical and Cognitive Function in Older Adults
2025 · Lauren Sparks, Cheehoon Ahn, et al. · Research Square
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Using Wearable Devices to Examine the Associations of Sedentary Behavior with Perceived and Performance Fatigability Among Older Adults: The Study of Muscle, Mobility and Aging (SOMMA)
2025 · Reagan E. Garcia, Anne B. Newman, et al. · Sensors · 3
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Rest Activity Rhythms and Their Association with Cardiorespiratory Fitness and Walking Energetics in Older Adults: Study of Muscle, Mobility, and Aging
2025 · MELISSA L. ERICKSON, TERRI L. BLACKWELL, et al. · Medicine & Science in Sports & Exercise · 2
Relationship of Multiple Sensory Impairments With Physical Performance in Older Adults in the Study of Muscle, Mobility and Aging
2025 · Atalie C Thompson, Tyler Mansfield, et al. · The Journals of Gerontology Series A · 4
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Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black
2025 · Paul M. Coen, Fanchao Yi, et al. · Aging Cell · 2
Mito-Modulatory Medication Use and Skeletal Muscle Bioenergetics Among Older Men and Women: The Study of Muscle, Mobility, and Aging
2025 · Howard J Phang, Jaclyn Bergstrom, et al. · The Journals of Gerontology Series A · 1
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