Ataxia-Telangiectasia: An emerging role for inflammation in driving neurodegeneration and premature ageing
Description: Ataxia-Telangiectasia (A-T) is a devastating genetic disease that arises in early childhood and causes patients to die in their twenties. To date there is no cure, and therapeutics are desperately needed. This project will use state-of-the-art brain organoids derived from stem cells of A-T patients in order to better understand this disease and evaluate novel drugs that target the molecular mechanisms that drive chronic inflammation and brain neurodegeneration in children with A-T.
Amount: A$437,400
Funding type: research
Funder scheme: Ideas Grants - Ideas Grants
Investigator: Julio Perez
Institution: University of Queensland
Funded outputs count: 7
Funder award ID: 2001408
OpenAlex ID: G27570526