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NBCe1-mediated Regulation of HCO3- is a Novel Mechanism Underlying Metabolic Reprogramming and Cystogenesis

Description: PROJECT NARRATIVE The proposed research will benefit both clinical and basic science fields by investigating the contributions of HCO3- buffering in type 2 diabetes and polycystic kidney disease. The proposed research is impactful because it probes a metabolic pathway implicated in type 2 diabetes and a proliferative pathway associated with polycystic kidney disease.
Funding type: fellowship
Funder scheme: F99
Start date: 2019-09-30
End date: 2022-03-29
Investigator: MATTHEW BROWN
Institution: MAYO CLINIC ROCHESTER
Subfield: Genetics
Funded outputs count: 9
Funder award ID: F99DK123834
OpenAlex ID: G2919268984
The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions
2022 · Matthew R. Brown, Damien Laouteouet, et al. · Cell Death and Disease · 17
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It’s What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets
2022 · Matthew R. Brown, Aleksey V. Matveyenko · Frontiers in Endocrinology · 5
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Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function
2021 · Matthew R. Brown, Satish K. Sen, et al. · Science Advances · 53
Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity
2021 · Anthony J. Treichel, Isabelle Finholm, et al. · Gastroenterology · 80
Electrogenic sodium bicarbonate cotransporter NBCe1 regulates pancreatic β cell function in type 2 diabetes
2021 · Matthew R. Brown, Heather Holmes, et al. · Journal of Clinical Investigation · 25
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Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
2021 · Naureen Javeed, Tracy K. Her, et al. · Cell Reports · 64
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Proinflammatory Cytokine Interleukin 1β Disrupts β-cell Circadian Clock Function and Regulation of Insulin Secretion
2020 · Naureen Javeed, Matthew R Brown, et al. · Endocrinology · 35
A method for the generation of human stem cell-derived alpha cells
2020 · Quinn P. Peterson, Adrian Veres, et al. · Nature Communications · 92
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Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity
2020 · Tracy K. Her, William S. Lagakos, et al. · American Journal of Physiology-Endocrinology and Metabolism · 23
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