A multi-systems study of HIV neuropathogenesis: genetics-neuropathology-behavior
Description: The impact of HIV-associated neurocognitive disorders (HAND) is substantial, affecting upwards of 50% of HIV-infected individuals; therefore, elucidating the neuropathogenesis of this disorder and identifying pharmaceutical targets will improve quality of life for tens of thousands within th United States alone. In recent years, a small number of genetic susceptibility loci have been identified that increase risk for HAND, suggesting that perturbation of the physiological pathways their gene products are involved in modifies HAND pathogenesis; however, nothing is known of what pathophysiological changes these genetic variants cause. Delineating this relationship will help to clarify the molecular and physiological pathways involved in HAND neuropathogenesis, and this will lead to identification of potential pharmaceutical targets.
Funding type: research
Funder scheme: R01
Start date: 2012-09-06
End date: 2018-05-31
Investigator: ANDREW J LEVINE
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 17
Funder award ID: R01MH096648
OpenAlex ID: G6911813621