A study of the combined effects of soy isoflavones and indigestible food components for prevention of osteoporosis.
Description: In the present study, we demonstrated that the combination of indigestible food components and soy isoflavone might prevent osteoporosis through prebiotic effect. We examined the modulation of microbiota to understand the mechanism underlying the prebiotic effect of this combination on bone metabolism in ovariectomised (OVX) mice. The combination of daidzein and indigestible glucan enhanced the production of equol by modulating the microbiota and mitigated the OVX-induced decline in bone mineral density of mice.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Yuko Tousen
Institution: National Institutes of Biomedical Innovation, Health and Nutrition
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 3
Funder award ID: 16K00901
OpenAlex ID: G2845075189