Advancing Multiplexed Isobaric Tag-based Strategies for Proteome Profiling
Description: NARRATIVE Isobaric tag-based quantitative proteomics is well-accepted as a leading methodology for multiplexed protein expression profiling. Current data acquisition strategies, however, lack either accuracy or depth, both of which are essential to high-throughput protein expression profiling. Here, we develop, evaluate, and apply a new real- time database searching platform (RTS-MS3) to alleviate the caveats associated with current methods and advance the technology further to significantly impact research across all aspects of human health.
Funding type: research
Funder scheme: R01
Start date: 2019-09-15
End date: 2025-08-31
Investigator: JOAO A PAULO
Institution: HARVARD MEDICAL SCHOOL
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Funded outputs count: 234
Funder award ID: R01GM132129
OpenAlex ID: G6796628015