Lands cycle and skeletal muscle insulin action
Description: Project Narrative Skeletal muscle insulin resistance accounts for ~90% of the reduction in insulin-stimulated glucose clearance in type 2 diabetic individuals. Alteration in lipid metabolism has been implicated for the pathogenesis of muscle insulin resistance, but the exact identify of the lipid-mediated mechanism that suppresses muscle insulin action in humans remains inconclusive. In this proposal, the role of lyso-phospholipids on skeletal muscle insulin sensitivity will be investigated.
Funding type: research
Funder scheme: R01
Start date: 2022-08-01
End date: 2027-07-31
Investigator: KATSUHIKO FUNAI
Institution: UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
Funded outputs count: 40
Funder award ID: R01DK127979
OpenAlex ID: G9000856152