Development of new therapy for neuromyelitis optica using its animal models and anti-AQP4 antibodies.
Description: We planed to establish new animal models for developing new therapy for neuromyelitis optica.In addition, we tried to elucidate a molecular mechanism for endocytosis of aquaporin-4 induced by binding of autoantibody called NMO-IgG. In this process, we found at least three amino-acid sequences responsible for endocytosis, intracellular trafficking, or degradation of aquaporin-4.
Amount: ¥17,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Yoichiro Abe
Institution: Keio University
Funded outputs count: 9
Funder award ID: 16H05134
OpenAlex ID: G2869944434