Ocular imaging biomarkers for attention deficit hyperactivity disorder (ADHD)
Description: Background: Attention-deficit hyperactivity disorder (ADHD) (ADHD) is the most common neurodevelopmental disorder among children. Reliable biomarkers can reduce difficulties of diagnosing ADHD.
Hypothesis to be tested：Quantitative metrics derived from optical coherence tomography (OCT) and digital retinal photographs have the great potential to serve as biomarkers for ADHD and its prognosis.
Design and subjects：This is a longitudinal population-based study for 3 years follow-up. A total of 2,000 children, including 500 ADHD children and 1500 normal children will be included and follow up 3 years.
Instruments：All the participants will be performed comprehensive ophthalmic examinations and OCT-A examination with a swept-source OCT. The retinal and choroidal metrics from OCT and retinal photographs are quantified by the fully automated imaging analysis systems.
Main outcome measures: The differences and longitudinal changes of retinal and choroidal parameters between ADHD and normal children.
Data analysis and expected results: Statistical analysis is performed using SPSS software. We expect that quantitative metrics from OCT and retinal photographs are significant differences in ADHD and normal children.
Funder: Health and Medical Research Fund
Amount: HKD 1,499,000
Funding type: grant
Funder scheme: HMRF - Advanced Medical Research
Start date: 2021-01-01
Investigator: Xiujuan ZHANG
Institution: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
Funded outputs count: 24
Funder award ID: 10210246
OpenAlex ID: G2893270202