Screening for unknown factors of reproductive and developmental abnormalities from the viewpoint of epigenetic and/or genetic fragility.
Description: Because of the diversity of the epigenome as well as the genome, a large number of pathologically unclear epigenetic variants can be found by ordinal analysis. In fact, we compared the DNA methylation of villous tissue in 24 cases who received assisted reproduction (treatment action including embryo manipulation) and 12 cases of spontaneous abortion, but no statistic differences could be detected. Therefore, the outlier test of DNA methylation was performed based on the method we previously reported (Kawai T, SciRep 2015), the abortion group after assisted reproduction had many outliers (ie, epigenetic fragments were observed). At present, detailed analysis of the features of DNA sequences that exhibited outliers is ongoing.
Amount: ¥6,500,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2017-06-30
End date: 2019-03-31
Investigator: KENCHIRO HATA
Institution: National Center for Child Health and Development
Funded outputs count: 6
Funder award ID: 17K19535
OpenAlex ID: G2894857071