The mechanisms of arsenic-induced carcinogenesis via fibroblast senescence
Description: Although senescent cells themselves irreversibly stop proliferation, they secrete multiple factors called senescence-associated secretory phenotype (SASP) such as cytokines, chemokines, and matrix metalloproteinases. SASP is known to involve tumorigenesis. In this study, we revealed arsenite exposure induced premature senescence and following SASP induction in human derived hepatic stellate cell line (fibroblast-like) LX-2. Furthermore, high level of gene expression of SASP factors were remained even after removing arsenite from culture medium. Thus, it was shown that the effect of arsenite exposure persist even after exposure to arsenite has ceased. The gene expression changes of SASP factors were also observed in human derived skin fibroblast cell line HFb16d after arsenite exposure. Therefore, it is suggested that induction of SASP factors in fibroblasts by arsenite exposure is involved in carcinogenesis.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Kazuyuki Okamura
Institution: National Institute for Environmental Studies
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Funded outputs count: 0
Funder award ID: 18K17363
OpenAlex ID: G29042161