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Origins and Functions of Mammalian Female Germline Stem Cells

Funding type: research
Funder scheme: R37
Start date: 1995-09-15
End date: 2017-01-31
Investigator: JONATHAN LEE TILLY
Institution: NORTHEASTERN UNIVERSITY
Funded outputs count: 36
Funder award ID: R37AG012279
OpenAlex ID: G6995554007
The obligate need for accuracy in reporting preclinical studies relevant to clinical trials: autologous germline mitochondrial supplementation for assisted human reproduction as a case study
2020 · Jonathan L. Tilly, Dori C. Woods · Therapeutic Advances in Reproductive Health · 3
Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation Embryos
2018 · Dori C. Woods, Konstantin Khrapko, et al. · Genes · 56
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Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility
2017 · Ning Wang, Chonthicha Satirapod, et al. · Scientific Reports · 45
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Single, long molecule PCR for the detection of rare mutations in Mitochondrial DNA
2017 · Housaiyin Li, Sofia Annis, et al. · The FASEB Journal · 1
Ovarian regeneration: The potential for stem cell contribution in the postnatal ovary to sustained endocrine function
2016 · Alisha M. Truman, Jonathan L. Tilly, et al. · Molecular and Cellular Endocrinology · 70
Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis
2016 · Adeel Safdar, Sofia Annis, et al. · Current Opinion in Genetics & Development · 44
Autologous Germline Mitochondrial Energy Transfer (AUGMENT) in Human Assisted Reproduction
2015 · Dori Woods, Jonathan Tilly · Seminars in Reproductive Medicine · 128
Reply to Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
2015 · Dori C Woods, Jonathan L Tilly · Nature Medicine · 27
Use of DEAD-box polypeptide-4 (Ddx4) gene promoter-driven fluorescent reporter mice to identify mitotically active germ cells in post-natal mouse ovaries
2014 · Eun-Sil Park, Jonathan L. Tilly · Molecular Human Reproduction · 54
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Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling
2013 · Eun-Sil Park, Dori C. Woods, et al. · Fertility and Sterility · 76
Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity
2013 · Anthony N. Imudia, Ning Wang, et al. · Fertility and Sterility · 44
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Germline Energetics, Aging, and Female Infertility
2013 · Jonathan L. Tilly, David A. Sinclair · Cell Metabolism · 220
Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries
2013 · Dori C Woods, Jonathan L Tilly · Nature Protocols · 147
Embryonic Stem Cell—Derived Granulosa Cells Participate in Ovarian Follicle Formation In Vitro and In Vivo
2013 · Dori C. Woods, Yvonne A. R. White, et al. · Reproductive Sciences · 31
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An Evolutionary Perspective on Adult Female Germline Stem Cell Function from Flies to Humans
2013 · Jonathan Tilly, Dori Woods · Seminars in Reproductive Medicine · 36
Purification of Oogonial Stem Cells From Adult Mouse and Human Ovaries: An Assessment of the Literature and a View Toward the Future
2012 · Dori C. Woods, Yvonne A. R. White, et al. · Reproductive Sciences · 83
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Prolonging the female reproductive lifespan and improving egg quality with dietary omega‐3 fatty acids
2012 · Deepika Nehra, Hau D. Le, et al. · Aging Cell · 124
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Oocyte Family Trees: Old Branches or New Stems?
2012 · Dori C. Woods, Evelyn E. Telfer, et al. · PLoS Genetics · 25
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The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice?
2012 · Dori C. Woods, Jonathan L. Tilly · Fertility and Sterility · 67
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
2012 · Yvonne A R White, Dori C Woods, et al. · Nature Medicine · 723
Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies
2011 · Kaisa Selesniemi, Ho-Joon Lee, et al. · Proceedings of the National Academy of Sciences · 201
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Systemic signals in aged males exert potent rejuvenating effects on the ovarian follicle reserve in mammalian females
2010 · Yuichi Niikura, Teruko Niikura, et al. · Aging · 41
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Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
2010 · Ning Wang, Lankai Guo, et al. · EMBO Reports · 26
Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
2010 · Seung Pyo Gong, Seung Tae Lee, et al. · Fertility and Sterility · 55
Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads
2010 · Ning Wang, Jonathan L. Tilly · Cell Cycle · 74
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