Analysis of projecitons from oxytocin neurons and oxytocin receptors
Description: Oxytocin neurons localized in the hypothalamus project to diverse brain regions, and are involved in diverse physiological responses such as social behavior, feeding, and stress response. We aimed to visualize and manipulate individual projection pathways of oxytocin neurons that have complex inputs and outputs. The purpose of this study was to elucidate individual functions or the functional relationship between the projections. Our results showed that the oxytocin receptor-expressing neurons in the prefrontal cortex includes projection neurons other than somatostatin-positive interneurons. In addition, we used retrograde infection of AAV vectors to investigate the projection pattern of oxytocin receptor-expressing neurons in the paraventricular nucleus.
Amount: ¥4,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Ayumu Inutsuka
Institution: Jichi Medical University
Funded outputs count: 11
Funder award ID: 16K08527
OpenAlex ID: G2920160540