Life Course Determinants of Epigenetic Age Acceleration and Subsequent Dementia
Description: PROJECT NARRATIVE Research that can evaluate the joint effect of social and biological forces on age-related disease is needed to more accurately inform future research and policy intervention that seeks to extend life expectancy and quality of life among older adults. This study capitalizes on a large pilot sample of epigenome-wide data from the Health and Retirement Study (HRS) (N=4,000) to understand the impact of socioeconomic status (SES), genotype, and risky health behaviors on disparities in epigenetic age acceleration and subsequent cognitive decline or Alzheimer's disease. Results from this study will inform future research geared towards connecting social, behavioral, genetic, and epigenetic factors to aging and cognitive function.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K99
Start date: 2017-07-15
End date: 2019-06-30
Investigator: LAUREN LUCIA SCHMITZ
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 14
Funder award ID: K99AG056599
OpenAlex ID: G4698856873