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Quantitative Assessment of Biological Age and Its Applications

Description: PROJECT NARRATIVE Quantitative assessment of progression through aging, based on reliable biomarkers, is critically important for both advancing the fundamental biology of aging and practical applications, such as testing interventions that extend lifespan. We propose to develop robust biomarkers of biological aging in mice and apply them to known and candidate longevity interventions. These biomarkers may be of wide use by the research community.
Funding type: research
Funder scheme: R01
Start date: 2020-08-01
End date: 2026-05-31
Investigator: VADIM N. GLADYSHEV
Institution: YALE UNIVERSITY
Subfield: Aging
Funded outputs count: 58
Funder award ID: R01AG065403
OpenAlex ID: G8550121789
2026 · Daniel S. Borrus, Raghav Sehgal, et al. · Aging Cell · 12
2026 · Raghav Sehgal, Daniel Borrus, et al. · Nature Medicine · 1
2026 · Kejun Ying, Seth Paulson, et al. · Nature Aging · 8
2026 · Jenel F. Armstrong, Shawn Wahi, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
2026 · Jessica Kasamoto, John González, et al. · Aging Cell · 1
2026 · Qingwen Chen, Varun B. Dwaraka, et al. · Nature Aging · 18
2025 · Kristin L. Dawson, Athena May Jean M. Carangan, et al. · Translational Psychiatry · 2
2025 · Daniel S. Borrus, Raghav Sehgal, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
2025 · John T. González, Olivia H. Scharfman, et al. · Mechanisms of Ageing and Development · 6
2025 · Erik Jacques, Chiara Herzog, et al. · Nature Aging · 10
2024 · Kejun Ying, Jinyeop Song, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 30
2024 · Zachary M. Harvanek, Raghav Sehgal, et al. · medRxiv · 4
2024 · Raghav Sehgal, Daniel Borrus, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 28
2024 · Kejun Ying, Alexander Tyshkovskiy, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 10
2024 · Chiara M. S. Herzog, Ludger J. E. Goeminne, et al. · Nature Aging · 111
2024 · Peter Niimi, Victoria Gould, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
2024 · Andrei E. Tarkhov, Thomas Lindstrom-Vautrin, et al. · Nature Aging · 84
2024 · Ali Doğa Yücel, Vadim N. Gladyshev · Nature Communications · 73
2024 · Mahdi Moqri, Chiara Herzog, et al. · Nature Medicine · 340
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