Thymic and Peripheral Aspects of T Cell Aging and Rejuvenation
Description: OVERALL- Narrative Older adults are disproportionally sensitive to infection and also suffer from elevated levels of cancer and of certain types of autoimmunity. A decline in immune function decisively contributes to this vulnerability, and a decline in T cell function and maintenance is responsible for much of that decline. This Program is designed to continue to significantly contribute to fundamental knowledge of T cell aging, but more importantly to yield one or more combined interventions that improve immune defense against infection in aged mouse models, paving the way for interventions to improve T cell immunity and healthspan in older humans, providing also for substantial health care and overall economy savings and benefits.
Funder: National Institute on Aging
Funding type: program
Funder scheme: P01
Start date: 2017-09-15
End date: 2028-02-29
Investigator: JANKO Z. NIKOLICH
Institution: UNIVERSITY OF ARIZONA
Funded outputs count: 81
Funder award ID: P01AG052359
OpenAlex ID: G9000900348