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Mentoring Diabetes Research in Oklahoma

Description: PROJECT NARRATIVE Diabetes research is a strategic research area at OUHSC. This COBRE is to mentor junior diabetes researcher and improve infrastructure of diabetes research in Oklahoma. These COBRE efforts will greatly enhance diabetes research. These researches will lead to improved prevention and treatment of diabetes, benefiting diabetic patients.
Funding type: program
Funder scheme: P30
Start date: 2017-07-01
End date: 2023-06-30
Investigator: YUN ZHENG LE
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Funded outputs count: 66
Funder award ID: P30GM122744
OpenAlex ID: G5545567088
Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safety
2025 · Dan Wu, Zhen Gong, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Endothelial-to-mesenchymal transition in the central nervous system: A potential therapeutic target to combat age-related vascular fragility
2025 · Michaela L. Vance, Dorina Nagy, et al. · Journal of Pharmacology and Experimental Therapeutics · 5
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RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration
2025 · Lilliana R. York, Hongwei Ma, et al. · International Journal of Molecular Sciences · 2
Functional ultrasound as a quantitative approach for measuring functional hyperemia in aging models
2025 · Jessica Pinckard, Sharon Negri, et al. · NeuroImage · 9
Targeting Myostatin as an Adjunct Treatment for the Preservation of Cardiometabolic and Skeletal Muscle Function in Type 1 Diabetes
2025 · Emily Nunan, Denton R. Huff, et al. · International Journal of Molecular Sciences · 2
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Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
2025 · Dan Wu, Venkateswararao Eeda, et al. · eLife · 2
Reviewer #1 (Public review): Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
2025 · eLife
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Author response: Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
2025 · Dan Wu, Venkateswararao Eeda, et al. · eLife
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Reviewer #3 (Public review): Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
2025 · eLife
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Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
2024 · Dan Wu, Venkateswararao Eeda, et al. · eLife · 6
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Author response: Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
2024 · Dan Wu, Venkateswararao Eeda, et al. · eLife
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Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin‐protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide‐gated channel deficiency
2024 · Fan Yang, Hongwei Ma, et al. · The FASEB Journal · 5
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The effects of time restricted feeding on age-related changes in the mouse retina
2024 · Cade A. Huston, Madison Milan, et al. · Experimental Gerontology · 6
Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects
2024 · Lauren R. Miller, Marisa A. Bickel, et al. · GeroScience · 17
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IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
2024 · Lauren R. Miller, Marisa A. Bickel, et al. · Frontiers in Aging Neuroscience · 13
The Effects of Nitric Oxide on Choroidal Gene Expression
2024 · Makenzie B. Merkley, Diana Soriano, et al. · Journal of Bioinformatics and Systems Biology · 1
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Single cell transcriptomics identifies distinct choroid cell populations involved in visually guided eye growth
2023 · Jody A. Summers, Kenneth L. Jones · Frontiers in Ophthalmology · 5
The ‘omics of obesity in B-cell acute lymphoblastic leukemia
2023 · Delaney K Geitgey, Miyoung Lee, et al. · JNCI Monographs · 9
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Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway
2023 · Lijie Dong, Rui Cheng, et al. · Diabetes · 30
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle
2023 · Miwa Hara, Wenjing Wu, et al. · Cell Reports · 19
Critical Role of VEGF as a Direct Regulator of Photoreceptor Function
2023 · Jianyan Hu, Meili Zhu, et al. · Advances in experimental medicine and biology · 3
Modulation of cGAS-STING signaling by PPARα in a mouse model of ischemia-induced retinopathy
2022 · Xiang Ma, Wenjing Wu, et al. · Proceedings of the National Academy of Sciences · 53
The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration
2022 · Yuhong Wang, Xiang Ma, et al. · PLoS ONE · 12
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miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo
2022 · Wenyi Luo, Youngsil Kim, et al. · Diabetes · 18
The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity
2022 · Christopher DeVera, Jendayi Dixon, et al. · International Journal of Molecular Sciences · 28
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