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调控衰老的关键表观遗传改变及重要信号通路

Amount: ¥2,900,000
Funding type: research
Funder scheme: 重点项目
Start date: 2013-01-01
End date: 2018-12-31
Investigator: 中军 周
Institution: 香港大学深圳研究院
Funded outputs count: 7
Funder award ID: 81330009
OpenAlex ID: G2969056989
TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
2018 · Guoliang Lyu, Yiting Guan, et al. · Nature Communications · 176
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Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation
2018 · Guoliang Lyu, Le Zong, et al. · Journal of Molecular Cell Biology · 3
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Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
2018 · Shrestha Ghosh, Sheung Kin Wong, et al. · eLife · 36
SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
2017 · Xiaolong Tang, Lei Shi, et al. · Nature Communications · 225
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MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
2016 · Hoi Leong Xavier Wong, Guoxiang Jin, et al. · Nature Communications · 87
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SIRTain regulators of premature senescence and accelerated aging
2015 · Shrestha Ghosh, Zhongjun Zhou · Protein & Cell · 31
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Genetics of aging, progeria and lamin disorders
2014 · Shrestha Ghosh, Zhongjun Zhou · Current Opinion in Genetics & Development · 65
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