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Renal repair effects of senolytic preconditioned mesenchymal stromal cells in diabetic kidney disease

Description: PROJECT NARRATIVE Diabetic kidney disease (DKD) is a devastating progressive disease with few treatment options to prevent progression to end-stage kidney failure. Stem cell transplantation, particularly using one’s own cells, is a promising novel treatment; however these stem cells may not function to full capacity, as needed to repair the damaged kidney. In this proposal, we will compare the ability of stem cells to repair the diabetic kidney before and after restoring stem cell health in order to optimize future cell-based therapy clinical trials.

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Funding type: research

Funder scheme: R03

Start date: 2020-04-01

End date: 2023-03-31

Investigator: LATONYA J HICKSON

Institution: MAYO CLINIC JACKSONVILLE

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

Funded outputs count: 11

Funder award ID: R03DK123492

OpenAlex ID: G7341720430