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GLUT1-dependent glycolysis regulates age-susceptible lung fibrosis

Description: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive, fatal lung disease that is more prevalent in the aging population. Glycolysis plays an important role in lung fibrogenesis and glucose transporter1 (GLUT1), the major glucose transporter in the lung, seems to regulate lung fibrosis. In this project we aim to investigate the mechanism by which GLUT1-dependent glycolysis mediates lung fibrogenesis, with the ultimate goal of supporting the development of therapies for IPF based on targeting GLUT1 and/or its upstream/downstream regulators.
Funding type: career_development
Funder scheme: K08
Start date: 2017-08-09
End date: 2023-07-31
Investigator: SOO JUNG CHO
Institution: WEILL MEDICAL COLL OF CORNELL UNIV
Field: Medicine
Funded outputs count: 20
Funder award ID: K08HL138285
OpenAlex ID: G5442003275
Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae
2024 · David G. Thomas, Jianjun Yang, et al. · Frontiers in Aging · 1
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Impact of Senolytic Treatment on Gene Expression in Aged Lung
2023 · Soo Jung Cho, Alexander Pronko, et al. · International Journal of Molecular Sciences · 3
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Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection
2023 · Soo Jung Cho, Alexander Pronko, et al. · Cells · 10
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The Role of Glutathione Reductase in Influenza Infection
2022 · Kyung Sook Hong, Kassandra Pagan, et al. · American Journal of Respiratory Cell and Molecular Biology · 14
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19
2022 · Mustafa Buyukozkan, Sergio Alvarez-Mulett, et al. · iScience · 21
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
2021 · Rebecca Harris, Jianjun Yang, et al. · International Journal of Molecular Sciences · 8
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Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis
2021 · William Whalen, Mustafa Buyukozkan, et al. · Thorax · 15
Cytokine signatures of end organ injury in COVID-19
2021 · Luis G. Gómez-Escobar, Katherine L. Hoffman, et al. · Scientific Reports · 50
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RIPK3 Activates MLKL-Mediated Necroptosis and Inflammasome Signaling During Streptococcus Infection
2021 · Hua-Rong Huang, Soo Jung Cho, et al. · American Journal of Respiratory Cell and Molecular Biology · 45
Decreased IDO1-dependent tryptophan metabolism in aged lung during influenza
2020 · Soo Jung Cho, Kyung Sook Hong, et al. · European Respiratory Journal · 22
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Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung
2020 · Ermias Jirru, Stefi Lee, et al. · Vaccines · 7
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DROSHA-Dependent miRNA and AIM2 Inflammasome Activation in Idiopathic Pulmonary Fibrosis
2020 · Soo Jung Cho, Mihye Lee, et al. · International Journal of Molecular Sciences · 28
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GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation
2019 · Soo Jung Cho, Jong-Seok Moon, et al. · Thorax · 93
Aging and Lung Disease
2019 · Soo Jung Cho, Heather W. Stout-Delgado · Annual Review of Physiology · 458
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DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis
2019 · Soo Jung Cho, Kyoung Sook Hong, et al. · Cells · 33
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Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
2019 · Kuei-Pin Chung, Chia-Lang Hsu, et al. · Nature Communications · 181
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Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone
2019 · Maria Plataki, Soo Jung Cho, et al. · Scientific Reports · 42
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Laminin α1 is a genetic modifier of TGF-β1–stimulated pulmonary fibrosis
2018 · Chang-Min Lee, Soo Jung Cho, et al. · JCI Insight · 43
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Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection
2017 · Soo Jung Cho, Maria Plataki, et al. · Experimental Gerontology · 18
NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection
2017 · Soo Jung Cho, Kristen Rooney, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 37
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