Molecular basis for tumor progression triggered by genetic heterogeneity of oncogenic activities.
Description: During cancer progression, clones of cells with different oncogenic mutations can interact with each other, leading to the promotion of cell proliferation and metastatic ability. To understand the molecular mechanisms of cancer progression triggered by the heterogeneity of cells with different oncogenic activities, we used a new Drosophila genetic mosaic technique called ‘coupled-MARCM’ technique. Through a genetic screen and subsequent genetic analyses, we found that a heterogeneity of cell clones with elevated Ras or Src oncoprotein activity triggers tumor progression in Drosophila imaginal epithelium. Furthermore, we elucidated the Notch-Delta-based mechanism of this tumor progression triggered by the interaction between Ras- and Src-activated cell clones.
Amount: ¥3,900,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Exploratory Research
Start date: 2013-04-01
End date: 2015-03-31
Investigator: Tatsushi IGAKI
Institution: Kyoto University
Funded outputs count: 4
Funder award ID: 25640064
OpenAlex ID: G2998157067