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Phase variation of virulence factors in Clostridium difficile

Description: Project Narrative The proposed research is relevant to the mission of the NIH because it will define mechanisms by which Clostridium difficile, an important human diarrheal pathogen, regulates the production of factors necessary for causing disease. The objective of the proposed research is to define a newly-identified mechanism impacting the expression of genes encoding flagella and the toxins that drive disease development. Understanding how C. difficile regulates these virulence factors may reveal new targets for development of preventive and therapeutic strategies.
Funding type: research
Funder scheme: R01
Start date: 2013-05-20
End date: 2024-08-31
Investigator: RITA TAMAYO
Institution: UNIV OF NORTH CAROLINA CHAPEL HILL
Field: Medicine
Funded outputs count: 32
Funder award ID: R01AI107029
OpenAlex ID: G6028708039
Phase Variation of Flagella and Toxins in Clostridioides difficile is Mediated by Selective Rho-dependent Termination
2024 · Mercedes A.H. Warren Norris, Dylan M. Plaskon, et al. · Journal of Molecular Biology · 9
Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile
2022 · Leila M. Reyes Ruiz, Kathleen A. King, et al. · PLoS Pathogens · 21
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Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides difficile infection
2022 · Dominika Trzilova, Mercedes A. H. Warren, et al. · Gut Microbes · 23
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Multiple Regulatory Mechanisms Control the Production of CmrRST, an Atypical Signal Transduction System in Clostridioides difficile
2022 · Elizabeth M. Garrett, Anchal Mehra, et al. · mBio · 26
Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations
2022 · Tamayo, R., Trzilova, D. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
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c-di-GMP Inhibits Early Sporulation in Clostridioides difficile
2021 · Adrianne N. Edwards, Caitlin L. Willams, et al. · mSphere · 22
Cyclic diguanylate regulates virulence factor genes via multiple riboswitches in Clostridium difficile
2021 · McKee, R.W., Tamayo, R., et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill) · 7
The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut
2021 · Jason W. Arnold, Jeffery Roach, et al. · Microbiome · 134
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Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations
2020 · Dominika Trzilova, Rita Tamayo · Trends in Genetics · 57
Rho factor mediates flagellum and toxin phase variation and impacts virulence in Clostridioides difficile
2020 · Dominika Trzilova, Brandon R. Anjuwon-Foster, et al. · PLoS Pathogens · 32
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Phase Variation of Clostridium Difficile Virulence Factors
2020 · Tamayo, R., Anjuwon-Foster, B.R. · Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2
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Enhancing bacterial survival through phenotypic heterogeneity
2020 · Leila M. Reyes Ruiz, Caitlin L. Williams, et al. · PLoS Pathogens · 68
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Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis
2019 · Pedro H. Oliveira, John W. Ribis, et al. · Nature Microbiology · 110
Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence
2019 · Elizabeth M. Garrett, Ognjen Sekulovic, et al. · PLoS Biology · 58
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An in vitro intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface
2019 · Raehyun Kim, Peter J Attayek, et al. · Biofabrication · 106
Single cell analysis of nutrient regulation of Clostridioides (Clostridium) difficile motility
2019 · David S. Courson, Astha Pokhrel, et al. · Anaerobe · 12
RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility
2019 · Adrianne N. Edwards, Brandon R. Anjuwon-Foster, et al. · mBio · 46
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Cyclic diguanylate riboswitches control bacterial pathogenesis mechanisms
2019 · Rita Tamayo · PLoS Pathogens · 122
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Cyclic Diguanylate Regulates Virulence Factor Genes via Multiple Riboswitches in Clostridium difficile
2018 · Robert W. McKee, Carissa K. Harvest, et al. · mSphere · 58
Characterization of Flagellum and Toxin Phase Variation in Clostridioides difficile Ribotype 012 Isolates
2018 · Brandon R. Anjuwon-Foster, Natalia Maldonado-Vazquez, et al. · Journal of Bacteriology · 40
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Genome-wide detection of conservative site-specific recombination in bacteria
2018 · Ognjen Sekulovic, Elizabeth Mathias Garrett, et al. · PLoS Genetics · 46
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Type IV Pili Promote Clostridium difficile Adherence and Persistence in a Mouse Model of Infection
2018 · Robert W. McKee, Naira Aleksanyan, et al. · Infection and Immunity · 101
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A Nutrient-Regulated Cyclic Diguanylate Phosphodiesterase Controls Clostridium difficile Biofilm and Toxin Production during Stationary Phase
2017 · Erin B. Purcell, Robert W. McKee, et al. · Infection and Immunity · 80
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A genetic switch controls the production of flagella and toxins in Clostridium difficile
2017 · Brandon R. Anjuwon-Foster, Rita Tamayo · PLoS Genetics · 101
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Cyclic diguanylate signaling in Gram-positive bacteria
2016 · Erin B. Purcell, Rita Tamayo · FEMS Microbiology Reviews · 77
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