Understanding the cellular basis for persistent immune activation in the central nervous system during virologically suppressed HIV
Description: PROJECT NARRATIVE Thanks to advances in HIV therapy, adults with HIV are living longer, but they now face the long-term effects of chronic viral infection and associated immune activation. This had led to an increase in conditions associated with chronic immune activation, including neurocognitive impairment. The objective of this proposal is to understand the cellular mechanisms that drive central nervous system immune activation, with the long-term goal of developing therapies to treat and prevent neurocognitive impairment in adults with HIV.
Funding type: career_development
Funder scheme: K23
Start date: 2018-09-25
End date: 2023-08-31
Investigator: SHELLI FARHADIAN (lead)
Institution: Yale University
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 33
Funder award ID: K23MH118999
OpenAlex ID: G1375843036