Extension of healthy longevity in body and periodontal tissue by NMN supplementation and senolytic treatment
Description: In this study, we challenged the development of a novel treatment for periodontal disease that targets cellular senescence, which is common in damaged organs of chronic age-related diseases. It has been reported that activity of NAD+ synthesis system and NAD+ dependent deacetylase, SIRT1 is reduced in the organs of the elderly ones. Therefore, we investigated the effects of treatment with NMN, an intermediate metabolite converted to NAD+, or senescent cell removal agents on periodontal cells. The results showed that treatment with NMN or an activator for this pathway resulted in the activation of exhausted mitochondrial function via SIRT3/6 and, in part, PGC1 alpha axis. These results suggest that the biological aging of the oral and total body of the elderly ones might be controlled by NMN supplementation.
Amount: ¥5,850,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2018-06-29
End date: 2020-03-31
Investigator: MOTOZO YAMASHITA
Institution: Osaka University
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 0
Funder award ID: 18K19644
OpenAlex ID: G3060480421