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Juniorverbünde in der Systemmedizin: Funktionelle Genomik im Zebrafisch zur Aufklärung molekularer Netzwerke der Herzinsuffizienz und Modellanalyse der Herzinsuffizienz (SYMBOL-HF), Universität Ulm

Amount: €1,275,000
Funding type: grant
Funder scheme: Systemmedizin
Start date: 2015-04-01
End date: 2018-12-31
Institution: Universität Ulm
Funded outputs count: 33
Funder award ID: 01ZX1407A
OpenAlex ID: G3079401970
Smarce1-dependent modulation of Stat3 signaling governs cardiomyocyte proliferation
2026 · Deung-Dae Park, Alena Boos, et al. · Biological Research
WASHC3 knockout disrupts mitochondrial protein homeostasis and energy metabolism in cardiomyocytes
2026 · Sujin Kim, Deung-Dae Park, et al. · Frontiers in Cardiovascular Medicine
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SMYD1-mediated mono-methylation of lysine K35 of sarcomeric myosin heavy chain (MHC) regulates sarcomere assembly and homeostasis in zebrafish and human iPSC-derived cardiomyocytes
2025 · Federica Diofano, Chidinma Amadi, et al. · Journal of Molecular and Cellular Cardiology · 3
SMYD1-mediated Mono-Methylation of Lysine K35 of the sarcomeric Myosin Heavy Chain (MHC) is fundamental for thick filament assembly in zebrafish and human iPSC-derived cardiomyocytes
2024 · Federica Diofano, Chidinma Amadi, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo
2023 · Janessa Hofeichner, Bernd Martin Gahr, et al. · Scientific Reports · 8
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Efficient cross-validation traversals in feature subset selection
2022 · Ludwig Lausser, Robin Szekely, et al. · Scientific Reports · 11
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Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
2022 · Francesca Ferrante, Benedetto Daniele Giaimo, et al. · Cell Death and Disease · 17
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CRISPR/Cas9-Mediated Constitutive Loss of VCP (Valosin-Containing Protein) Impairs Proteostasis and Leads to Defective Striated Muscle Structure and Function In Vivo
2022 · Philipp Voisard, Federica Diofano, et al. · International Journal of Molecular Sciences · 14
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Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish
2021 · Anja Bühler, Bernd M. Gahr, et al. · PLoS Genetics · 17
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Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish
2021 · Deung-Dae Park, Bernd M. Gahr, et al. · International Journal of Molecular Sciences · 21
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Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish
2021 · Manuel Rattka, Sören Westphal, et al. · Journal of Molecular and Cellular Cardiology · 18
Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency
2020 · Federica Diofano, Karolina Weinmann, et al. · PLoS Genetics · 33
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Assessing phenotype order in molecular data
2019 · Ludwig Lausser, Lisa M. Schäfer, et al. · Scientific Reports · 8
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Representing dynamic biological networks with multi-scale probabilistic models
2019 · Alexander Groß, Barbara Kracher, et al. · Communications Biology · 34
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Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species
2018 · Ludwig Lausser, Lea Siegle, et al. · Biomolecules · 2
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Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish
2018 · Alexander Pott, Maryam Shahid, et al. · Biomolecules · 12
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Genetics of Cardiovascular Disease: Fishing for Causality
2018 · Christoph Paone, Federica Diofano, et al. · Frontiers in Cardiovascular Medicine · 27
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Identification of biological mechanisms by semantic classifier systems
2018 · Ludwig Lausser, Florian Schmid, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish
2018 · Alexander Pott, Sarah Bock, et al. · Journal of Molecular and Cellular Cardiology · 33
New perspectives: systems medicine in cardiovascular disease
2018 · Frank Kramer, Steffen Just, et al. · BMC Systems Biology · 25
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Automatic Screening for Perturbations in Boolean Networks
2018 · Julian D. Schwab, Hans A. Kestler · Frontiers in Physiology · 31
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A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
2018 · Lea Siegle, Julian D. Schwab, et al. · PLoS ONE · 36
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Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response
2018 · Christoph Paone, Steven Rudeck, et al. · Biochemical and Biophysical Research Communications · 9
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Ordinal Classifiers Can Fail on Repetitive Class Structures
2018 · Lausser, Ludwig, Schäfer, Lisa M., et al. · Repository KITopen (Karlsruhe Institute of Technology) · 2
Stability of Signaling Pathways during Aging—A Boolean Network Approach
2017 · Julian Schwab, Lea Siegle, et al. · Biology · 19
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