PQ#12; Targeting Nampt-mediated NAD+ metabolism in chemobrain
Description: PROJECT NARRATIVE In the United States, cognitive dysfunction stemming from chemotherapy is a major adverse condition affecting approximately 14 million cancer survivors. Unfortunately, the underlying pathophysiological mechanisms remain unknown. The findings of this proposal are crucial towards elucidating a role for the Nampt-mediated NAD+ metabolic pathway in improving neuronal and cognitive dysfunction resulting from chemobrain. This understanding will provide insight into development of novel therapeutic interventions that target chemotherapy-induced cognitive dysfunction.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2019-08-08
End date: 2025-07-31
Investigator: MI-HYEON JANG
Institution: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 17
Funder award ID: R01CA242158
OpenAlex ID: G2069264790