Investigation of the pathogenesis of pulmonary hypertension focused on the impact of intestinal dysbiosis
Description: In this study, it was reported that gut microbiota plays a causative role in the development of pulmonary arterial hypertension (PAH). We investigated the following two points: (1) whether the alteration of gut microbiota in pulmonary hypertension exists and (2) whether the alteration is a cause or a result of the development of pulmonary hypertension. First, we collected fecal samples from PAH rats (Su/Hx) and control rats. Thereafter, 16s rRNA sequencing was conducted. The 16s RNA analysis demonstrated the difference in the compositions of gut microbiota between the two groups. Moreover, Su/Hx rats were treated with four antibiotics (Su/Hx + ABx) in order to alter the gut microbiota. The Su/Hx + ABx rats had a different composition of gut microbiota and less severe pulmonary hypertension compared to Su/Hx rats. These results suggested that gut microbiota can be a causative factor in the development of PAH and may offer a new approach in the prevention of PAH in the future.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Nobuhiro TANABE
Institution: Chiba University
Funded outputs count: 19
Funder award ID: 17K09604
OpenAlex ID: G3107986892