Regulation of Proteostasis and Tauopathy by Maltose-induced Signaling
Description: PROJECT NARRATIVE Decline in proteostasis is a defining feature of aging and Alzheimer’s disease (AD) but the signaling pathways responsible for protein quality control are only in part known. We have recently found an important role for the disaccharide maltose in preserving proteostasis in the central nervous system during aging. In this application, we propose to investigate the mechanisms responsible for the effects of maltose-induced signaling on improving proteostasis, which may help design effective therapies to preserve and/or reinstate proteostasis in AD patients.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2024-06-01
End date: 2029-02-28
Investigator: FABIO DEMONTIS (lead)
Institution: St. Jude Children's Research Hospital
Funded outputs count: 12
Funder award ID: R01AG075869
OpenAlex ID: G9000919840