Regulation of autophagy in podocyte by the transcription factor MAFB
Description: By regulating the transcription factor MAFB using recombinant technology, we found that MAFB has a cytoprotective effect through autophagy activation. We confirmed that MAFB induced polyamine metabolizing enzymes, increased spermidine levels, and spermidine induced autophagy. These results revealed the existence of a molecular mechanism of MAFB-spermidine-autophagy in podocytes, suggesting that it may be a new therapeutic target.
Amount: ¥3,900,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Kosuke Yamahara
Institution: Shiga University of Medical Science
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 18K15999
OpenAlex ID: G3135588696