Pannexin Channels In Vascular Physiology & Inflammation
Description: OVERALL PROJECT NARRATIVE Signaling via extracellular nucleotides (purinergic signaling) critically regulates vascular physiology and inflammation in tissues. One mode by which cells release nucleotides is via the newly discovered pannexin channels. Further, our recent work suggests that these pannexin channels also release other metabolites that can be part of the inter-cellular communication. Recent genome wide expression analyses have linked altered expression of Pannexin 1 to cardiovascular disease, metabolic syndromes, and airway inflammation. Therefore, the studies of this P01 project, which have identified specific compounds capable of activating and inhibiting the pannexin channels in the current funding period, will be used to modulate the function pannexin channels in different tissue contexts, tissue pathologies such as fibrosis, as well as tissue inflammation. In turn, we expect these studies to identify potential points for therapeutic targeting of the pannexin channels in specific human diease conditions.
Funding type: program
Funder scheme: P01
Start date: 2014-08-01
End date: 2025-05-31
Investigator: DOUGLAS A. BAYLISS
Institution: UNIVERSITY OF VIRGINIA
Topic: Connexins and lens biology
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 136
Funder award ID: P01HL120840
OpenAlex ID: G3945699462