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Impact of Heightened UPR Activation on Inflammasome Responses to Influenza and Secondary Streptococcus pneumoniae Infection in Aged Lung

Description: Project Narrative This proposal will investigate mechanistic pathways that underlie impaired immune responses to pathogenic stimuli in aged lung. Knowledge of signaling cascades and mechanisms utilized in lung as the host ages will aid in the design of therapeutics that reduce serious disease and improve clinical outcomes in the elderly.
Funding type: research
Funder scheme: R01
Start date: 2018-05-01
End date: 2024-04-30
Investigator: HEATHER WINONA STOUT DELGADO
Institution: WEILL MEDICAL COLL OF CORNELL UNIV
Funded outputs count: 18
Funder award ID: R01AG056699
OpenAlex ID: G2063879647
Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae
2024 · David G. Thomas, Jianjun Yang, et al. · Frontiers in Aging · 1
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Impact of Senolytic Treatment on Gene Expression in Aged Lung
2023 · Soo Jung Cho, Alexander Pronko, et al. · International Journal of Molecular Sciences · 3
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Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection
2023 · Soo Jung Cho, Alexander Pronko, et al. · Cells · 10
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The Role of Glutathione Reductase in Influenza Infection
2022 · Kyung Sook Hong, Kassandra Pagan, et al. · American Journal of Respiratory Cell and Molecular Biology · 14
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
2021 · Rebecca Harris, Jianjun Yang, et al. · International Journal of Molecular Sciences · 8
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Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis
2021 · William Whalen, Mustafa Buyukozkan, et al. · Thorax · 15
Cytokine signatures of end organ injury in COVID-19
2021 · Luis G. Gómez-Escobar, Katherine L. Hoffman, et al. · Scientific Reports · 50
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RIPK3 Activates MLKL-Mediated Necroptosis and Inflammasome Signaling During Streptococcus Infection
2021 · Hua-Rong Huang, Soo Jung Cho, et al. · American Journal of Respiratory Cell and Molecular Biology · 45
Decreased IDO1-dependent tryptophan metabolism in aged lung during influenza
2020 · Soo Jung Cho, Kyung Sook Hong, et al. · European Respiratory Journal · 22
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Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model
2020 · Elizabeth Perez, Jonathan R Baker, et al. · The Journal of Immunology · 28
Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung
2020 · Ermias Jirru, Stefi Lee, et al. · Vaccines · 7
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Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly
2020 · Stefi F. Lee, Rebecca Harris, et al. · Translational research · 11
DROSHA-Dependent miRNA and AIM2 Inflammasome Activation in Idiopathic Pulmonary Fibrosis
2020 · Soo Jung Cho, Mihye Lee, et al. · International Journal of Molecular Sciences · 28
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GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation
2019 · Soo Jung Cho, Jong-Seok Moon, et al. · Thorax · 93
Aging and Lung Disease
2019 · Soo Jung Cho, Heather W. Stout-Delgado · Annual Review of Physiology · 458
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DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis
2019 · Soo Jung Cho, Kyoung Sook Hong, et al. · Cells · 33
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Importance of Mcl-1 for Alveolar Macrophage Apoptosis–associated Bacterial Killing
2019 · Heather W. Stout-Delgado · American Journal of Respiratory and Critical Care Medicine · 1
Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone
2019 · Maria Plataki, Soo Jung Cho, et al. · Scientific Reports · 42
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