Integrating craniofacial morphology, oral function, temporomandibular biomechanics and mechanobiology to determine sex-specific TMJ pathophysiology in humans
Description: Project Narrative The proposed experiments utilize critical biomechanical information and approaches to understanding the temporomandibular joint (TMJ) and associated disc, which were determined by our previous study of pig TMJ. It extends that approach into human patients, and combines it with state of the art patient-specific craniofacial morphology combined with oral function biomechanics. This approach will test healthy males and females, in comparison with those who have TMJ dysfunction, to determine why females get TMJ dysfunction and disease 3-8 times more frequently than males.
Funding type: research
Funder scheme: R01
Start date: 2012-03-06
End date: 2027-01-31
Investigator: HAI YAO
Institution: CLEMSON UNIVERSITY
Funded outputs count: 69
Funder award ID: R01DE021134
OpenAlex ID: G9000886197