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A modeling & simulation approach to develop the personalized doing system of neuropsychiatric drug therapy

Description: In this study, we conducted the clinical research to develop the personalized dosing system of neuropsychiatric drugs. Briefly, we determined the extent of influence of several genotypes on the pharmacokinetics and pharmacodynamics (including weight gain as an adverse reactions) of antidepressant: paroxetine, mood stabilizers: valproic acid and carbamazepine, antipsychotics: risperidone and olanzapine, and we proposed the novel dosing regimen for these drugs based on the patient information using the nonlinear mixed effect model.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,810,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2016-04-01

End date: 2019-03-31

Investigator: Junji SARUWATARI

Institution: Kumamoto University

Funded outputs count: 9

Funder award ID: 16K08406

OpenAlex ID: G3156732882

The associations of the number of medications and the use of anticholinergics with recovery from tubal feeding: a longitudinal hospital-based study

2020 · Keiji Takata, Kentaro Oniki, et al. · BMC Geriatrics · 6

The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties

2020 · Kentaro Oniki, Hirofumi Nohara, et al. · Scientific Reports · 16

Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions

2020 · Kentaro Oniki, Taisei Kawakami, et al. · Scientific Reports · 16

A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population

2020 · Narumi Muto, Kentaro Oniki, et al. · Diabetes Metabolic Syndrome and Obesity · 7

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

2019 · Yuki Sakamoto, Kentaro Oniki, et al. · Disease Markers · 17

A Multifaceted Approach regarding the Association of the DsbA-L Gene with the Risk of Obesity-related Diseases Based on Clinical Pharmacogenetics

2018 · Kentaro Oniki, Junji Saruwatari · YAKUGAKU ZASSHI · 2

Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats

2018 · Junji Saruwatari, Chao Dong, et al. · Scientific Reports · 5

Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein (DsbA‐L) Polymorphism on the Weight Status

2018 · Kentaro Oniki, Takehisa Watanabe, et al. · CPT Pharmacometrics & Systems Pharmacology · 15

Association between oxidative stress-related genes polymorphisms and metabolic abnormalities among schizophrenia patients

2017 · Kentaro Oniki, Masamichi Ishioka, et al. · Clinical Neuropsychopharmacology and Therapeutics · 3