Loss of nuclear integrity is sufficient to induce age-associated changes and Alzheimer's pathology in hPSC-derived cortical neurons.
Description: Project Narrative This study will establish an hPSC-derived model of Alzheimer’s Disease for drug screening and disease modelling purposes. The proposed experiments will elucidate any causal relationship or potential crosstalk between age-associated decline in nuclear lamina and transport activity, potentially identifying a master regulator of nuclear and cellular aging. The induced aging strategies outlined in this proposal could further be applied to non-neuronal cell types for modelling late-onset diseases of other lineages.
Funder: National Institute on Aging
Funding type: fellowship
Funder scheme: F31
Start date: 2020-05-13
End date: 2023-05-12
Investigator: ANDREW MINOTTI
Institution: WEILL MEDICAL COLL OF CORNELL UNIV
Funded outputs count: 7
Funder award ID: F31AG067709
OpenAlex ID: G8406219770