Long-lived proteins as pillars of mitochondrial architecture in rodent brains
Description: PROJECT NARRATIVE Cells have evolved an intricate multilevel protein quality control system to maintain a pristine mitochondrial proteome and ensure proper function. Here, we investigate long-lived mitochondrial proteins that we unexpectedly found to persist for months in the mammalian brain. The results of the proposed research will elucidate several important aspects of these exceptional proteins and investigate new aspects of mitochondria fitness and structure as it relates to cells' survival and longevity.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R21
Start date: 2022-09-15
End date: 2025-08-31
Investigator: JEFFREY NICHOLAS SAVAS
Institution: NORTHWESTERN UNIVERSITY AT CHICAGO
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 13
Funder award ID: R21AG072343
OpenAlex ID: G3911578903