Molecular epidemiological study toward personalized prevention of lifestyle-related diseases in community residents
Description: We examined relationships between the ALDH2 and ADH1B genotypes, alcohol intake behavior and systolic blood pressure (SBP), brachial-ankle pulse wave velocity (baPWV) in 2218 community residents (986 men and 1232 women). Significant associations between alcohol intake and SBP were observed both in ALDH2*1/*1 and ALDH2*2 in men. In women, the associations were observed in ALDH2*1/*1 but not in ALDH2*2. Furthermore, the associations were observed both in ADH1B*1 and ADH1B*2/*2 in men. In women, the associations were observed in ADH1B*2/*2 but not in ADH1B*1. The associations between alcohol intake and baPWV were suggested both in ALDH2*1/*1 and ALDH2*2 in men, although not significant. In women, the tendency of the associations were indicated in ALDH2*1/*1 but not in ALDH2*2. In both men and women, the associations were observed in ADH1B*2/*2 but not in ADH1B*1.
Amount: ¥4,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Tatsuya Takeshita
Institution: Wakayama Medical University
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 4
Funder award ID: 16K09104
OpenAlex ID: G3206463059