Single cell transcriptomic study of alcohol use
Description: /// PROJECT NARRATIVE \\\ Alcohol use disorder (AUD) is a common medical condition characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. To better understand gene expression changes in the brain associated with AUD, we propose single nuclei sequencing of the brain transcriptome in multiple brain regions to identify cell-type specific gene expression differences. Successful completion of this project will yield (i) unprecedented insights into AUD disease mechanisms, (ii) possible blood biomarkers of genes differentially expressed in brain, and (iii) lay the foundation for functional follow-up studies and, eventually, novel highly specific clinical interventions for improving AUD treatment.
Funding type: research
Funder scheme: R01
Start date: 2023-09-01
End date: 2028-07-31
Investigator: KAROLINA ANNA ABERG
Institution: VIRGINIA COMMONWEALTH UNIVERSITY
Funded outputs count: 8
Funder award ID: R01AA030116
OpenAlex ID: G9000857611