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Improving Primordial Follicle Survival After Transplantation of Cryopreserved Hum

Description: Premature ovarian failure and infertility are significant consequences of cancer treatments with major impact on quality of life and public health. Transplantation of cryopreserved ovarian tissue is one of the emerging key fertility preservation strategies in cancer patients but the technique is limited due to low survival of eggs in ovarian tissue. The overall goal of this project is to enhance ovarian graft survival and function by developing pharmacological treatments that can enhance new vessel development in ovarian transplants.
Funding type: research
Funder scheme: R21
Start date: 2011-07-01
End date: 2014-06-30
Investigator: KUTLUK H OKTAY
Institution: NEW YORK MEDICAL COLLEGE
Field: Medicine
Funded outputs count: 38
Funder award ID: R21HD061259
OpenAlex ID: G7207300029
Perinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis
2024 · Murat Erden, Esra Uyanik, et al. · American Journal of Obstetrics and Gynecology · 32
Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
2024 · Joshua Johnson, Sean D. Lawley, et al. · American Journal of Obstetrics and Gynecology · 20
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Comparison of orthotopic and heterotopic autologous ovarian tissue transplantation outcomes
2023 · Kutluk H. Oktay, Loris Marin · Fertility and Sterility · 37
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Safety of ovarian cryopreservation and transplantation in patients with acute leukemia: a case series
2023 · Murat Sönmezer, Yavuz Emre Şükür, et al. · American Journal of Obstetrics and Gynecology · 36
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Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
2022 · Alla Vash-Margita, Katarzyna Szymanska-Vandendriessche, et al. · Fertility and Sterility · 7
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Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data
2021 · Kutluk Oktay, Loris Marin, et al. · Fertility and Sterility · 57
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Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
2021 · Kutluk H. Oktay, Loris Marin, et al. · Trends in Molecular Medicine · 50
Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate
2020 · Robert Stobezki, Shiny Titus, et al. · Reproductive Sciences · 21
History, Evolution and Current State of Ovarian Tissue Auto-Transplantation with Cryopreserved Tissue: a Successful Translational Research Journey from 1999 to 2020
2020 · Loris Marin, Giuliano Bedoschi, et al. · Reproductive Sciences · 73
Application of Decellularized Tissue Scaffolds in Ovarian Tissue Transplantation
2017 · Enes Taylan, Kutluk Oktay · Methods in molecular biology · 14
Chemotherapy-Induced Damage to Ovary: Mechanisms and Clinical Impact
2016 · Giuliano Bedoschi, Paula Andrea Navarro, et al. · Future Oncology · 361
First pregnancies, live birth, and in vitro fertilization outcomes after transplantation of frozen-banked ovarian tissue with a human extracellular matrix scaffold using robot-assisted minimally invasive surgery
2015 · Kutluk Oktay, Giuliano Bedoschi, et al. · American Journal of Obstetrics and Gynecology · 149
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Fertility Preservation in Women with Turner Syndrome: A Comprehensive Review and Practical Guidelines
2015 · Kutluk Oktay, Giuliano Bedoschi, et al. · Journal of Pediatric and Adolescent Gynecology · 210
Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer
2015 · Kutluk Oktay, Volkan Turan, et al. · Journal of Clinical Oncology · 221
Oocyte Cryopreservation for Fertility Preservation in Postpubertal Female Children at Risk for Premature Ovarian Failure Due to Accelerated Follicle Loss in Turner Syndrome or Cancer Treatments
2014 · K. Oktay, G. Bedoschi · Journal of Pediatric and Adolescent Gynecology · 110
Triggering final oocyte maturation with gonadotropin-releasing hormone agonist (GnRHa) versus human chorionic gonadotropin (hCG) in breast cancer patients undergoing fertility preservation: an extended experience
2014 · Jhansi Reddy, Volkan Turan, et al. · Journal of Assisted Reproduction and Genetics · 90
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Sexual and fertility adverse effects associated with chemotherapy treatment in women
2014 · Volkan Turan, Kutluk Oktay · Expert Opinion on Drug Safety · 43
Fertility preservation during cancer treatment: clinical guidelines
2014 · Kutluk Oktay, Kenny Rodriguez-Wallberg · Cancer Management and Research · 147
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Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death
2013 · F. Li, V. Turan, et al. · Human Reproduction · 175
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Utility of GnRH-Agonists for Fertility Preservation in Women with Operable Breast Cancer: Is It Protective?
2013 · Giuliano Bedoschi, Volkan Turan, et al. · Current Breast Cancer Reports · 26
Safety and feasibility of performing two consecutive ovarian stimulation cycles with the use of letrozole-gonadotropin protocol for fertility preservation in breast cancer patients
2013 · Volkan Turan, Giuliano Bedoschi, et al. · Fertility and Sterility · 108
Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis
2013 · Aylin Pelin Cil, Heejung Bang, et al. · Fertility and Sterility · 185
Current approach to fertility preservation by embryo cryopreservation
2013 · Giuliano Bedoschi, Kutluk Oktay · Fertility and Sterility · 110
Fertility preservation in young breast cancer patients: addressing individual patient needs
2013 · Kenny Rodriguez-Wallberg, Kutluk Oktay · Breast Cancer Management
Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans
2013 · Shiny Titus, Fang Li, et al. · Science Translational Medicine · 523
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