Brain connectivity and response to Tai Chi in geriatric depression
Description: PUBLIC HEALTH RELEVANCE: We will examine the neural mechanisms of brain connectivity in response to Tai Chi Chih compared to stretching exercise and health and wellness education seminar using fMRI biomarkers of emotional regulation and working memory in 330 older un-medicated participants with depressive symptoms. Overall, we will establish whether variations in emotional regulation and brain connectivity moderate or predict mood and functional improvement linked with TCC using markers of fMRI brain emotional processing over the course of the 12 week interventions with either TCC or Health and Wellness Education or Stretching exercise controls, and will follow maintenance of response in a 6-month follow-up. We anticipate that clinical and cognitive benefits will be accompanied by the changes in brain connectivity using fMRI measures of emotional processing and memory.
Funding type: research
Funder scheme: R01
Start date: 2015-04-01
End date: 2021-03-31
Investigator: HELEN LAVRETSKY
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 31
Funder award ID: R01AT008383
OpenAlex ID: G2602374077