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Clinical Genomics and Experimental Therapeutics

Funding type: intramural
Funder scheme: ZIA
Investigator: FALK LOHOFF
Institution: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
Funded outputs count: 52
Funder award ID: ZIAAA000242
OpenAlex ID: G9000862635
GLP-1 Receptor Agonist and GIP/GLP-1 Receptor Dual Agonist Therapeutics at the Intersection of Alcohol Use Disorder, Obesity, and Cardiometabolic Dysfunction
2026 · Joshua Reitz, Daniel B. Rosoff, et al. · Biological Psychiatry Global Open Science
Alcohol Use Disorder With Metabolic Dysfunction Is Associated With Adverse Health Impacts in a United States Clinical Setting
2026 · Alexandra C. Wagner, Jeesun Jung, et al. · Addiction Biology · 1
Genetic evidence that FGF21 signaling reduces problematic alcohol use and alcohol-related liver disease
2026 · Daniel B. Rosoff, Josephin Wagner-DeTurck, et al. · Journal of Hepatology · 4
Treatment approaches for alcohol use disorder with metabolic dysfunction
2025 · Alexandra C. Wagner, Jeesun Jung, et al. · Pharmacology & Therapeutics · 2
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study
2025 · Joshua Reitz, Daniel B. Rosoff, et al. · Molecular Psychiatry · 13
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DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium
2025 · Lea Zillich, Sofia D’Augello, et al. · medRxiv · 2
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Alcohol and aging: Next‐generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder
2025 · Tyler A. Perlstein, Jeesun Jung, et al. · Alcoholism Clinical and Experimental Research · 5
A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking
2024 · Daniel B. Rosoff, Josephin Wagner, et al. · Nature Human Behaviour · 14
Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations
2024 · Daniel B. Rosoff, Josephin Wagner, et al. · Diabetes · 10
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Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder
2024 · Lea Zillich, Metin Cetin, et al. · Alcoholism Clinical and Experimental Research · 13
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Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study
2024 · Daniel B. Rosoff, Andrew S. Bell, et al. · Circulation Genomic and Precision Medicine · 4
Multi‐omics analysis of alcohol effects on the liver in young and aged mice
2023 · Lea Zillich, Josephin Wagner, et al. · Addiction Biology · 7
Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries
2023 · Daniel B. Rosoff, Andrew S. Bell, et al. · Cellular and Molecular Gastroenterology and Hepatology · 15
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Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
2023 · Daniel B. Rosoff, Lucas A. Mavromatis, et al. · Nature Aging · 81
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Multi-omic underpinnings of epigenetic aging and human longevity
2023 · Lucas A. Mavromatis, Daniel B. Rosoff, et al. · Nature Communications · 60
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PCSK9 Base Editing Therapeutics and Ischemic Stroke
2022 · Josephin Wagner, Andrew S. Bell, et al. · ACS Chemical Neuroscience · 5
Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function
2022 · Daniel B. Rosoff, Andrew S. Bell, et al. · Journal of the American College of Cardiology · 126
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Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder
2022 · Jeesun Jung, Daniel L. McCartney, et al. · Biological Psychiatry · 26
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Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging
2022 · Jeesun Jung, Daniel L. McCartney, et al. · Molecular Psychiatry · 21
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Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder
2022 · Falk W. Lohoff · Frontiers in Psychiatry · 32
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Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target
2021 · Falk W. Lohoff, Toni-Kim Clarke, et al. · Molecular Psychiatry · 47
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Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections
2021 · Daniel B. Rosoff, Joyce Yoo, et al. · Communications Biology · 40
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PCSK9 and the Gut-Liver-Brain Axis: A Novel Therapeutic Target for Immune Regulation in Alcohol Use Disorder
2021 · Ji Soo Lee, Emma M. O’Connell, et al. · Journal of Clinical Medicine · 31
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A genetically-informed study disentangling the relationships between tobacco smoking, cannabis use, alcohol consumption, substance use disorders and respiratory infections, including COVID-19
2021 · Daniel B. Rosoff, Joyce Yoo, et al. · medRxiv · 6
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Epigenetics of alcohol use disorder—A review of recent advances in DNA methylation profiling
2021 · Martha J. Longley, Jisoo Lee, et al. · Addiction Biology · 55
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