A systems approach to uncover upstream activators and common downstream pathways of neurodegeneration in a Drosophila model
Description: PROJECT NARRATIVE Although genetics can play an important role in most neurodegenerative disorders, most cases are sporadic in origin, meaning that no family history exists and no known genetic cause has been identified. It is thought that environmental forces impact the onset and perhaps progression of neurodegeneration. This likely is true for Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. This proposal will use a systematic approach in Drosophila to identify environmental and lifestyle perturbations that impact a series of neurodegenerative biomarkers and phenotypes. In addition, we will seek to identify common downstream cellular impacts that are shared across relevant environmental perturbations.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2017-09-15
End date: 2022-03-31
Investigator: JOSHUA T DUBNAU
Institution: STATE UNIVERSITY NEW YORK STONY BROOK
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 9
Funder award ID: RF1AG057338
OpenAlex ID: G2621353057