Cellular and Tissue Rejuvenation through Transcriptional Reprogramming
Description: A fundamentally new approach to the treatment and prevention of age-related diseases is to target the root cause of aging. Under this new paradigm, rejuvenation of aging human tissues and organs represents a promising and exciting direction. Previously we identified 4 transcription factors that can rejuvenate human fibroblast cells aged in vitro through continuous passaging. This project proposes to test the rejuvenating effect of these factors in human fibroblast cells aged inside human body, and in mouse liver. New technologies will be developed to systematically identify combinations of transcription factors for rejuvenation. The proposed research will set a unique stage for discovering combinations of small molecule drugs for rejuvenation therapy.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2023-08-01
End date: 2028-04-30
Investigator: HAO LI
Institution: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Funded outputs count: 4
Funder award ID: R01AG083524
OpenAlex ID: G9000865344