A study to elucidate mechanism, by which periodontists inducing memory impairment and to determine effect of its intervention on progression of dementia.
Description: We found that periodontitis caused memory impairment accompanied by increased levels of Ab deposition in Alzheimer’s disease mouse model. Brain inflammation demonstrated by increased levels of cytokines (IL-6, and TNFa) was found in mice with periodontitis. These results indicated that oral chronic inflammation caused by periodontitis invades into brain where cytokines levels increase and leading to increase Ab generation and Ab deposition, causing memory inflammation. We also found that intervention by treatment of periodontitis attenuated progression of memory deterioration in demented patients with Alzheimer’s disease.
Amount: ¥17,160,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Makoto Michikawa
Institution: Nagoya City University
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Funded outputs count: 15
Funder award ID: 16H05559
OpenAlex ID: G3274765186