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IGF-1, Oxidative Stress and Cardiovascular Aging

Funding type: research
Funder scheme: R03
Start date: 2002-09-01
End date: 2004-08-31
Investigator: JUN REN (lead)
Funded outputs count: 28
Funder award ID: R03AG021324
OpenAlex ID: G166842214
Corrigendum to “Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy” [Biochim. Biophys. Acta Mol. Basis Dis. 2019 Jul 1; 1865(7): 1865–1875. doi: 10.1016/j.bbadis.2018.08.011]
2024 · S. Wang, M.R. Kandadi, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases
2018 · Jun Ren, Yingmei Zhang · Trends in Pharmacological Sciences · 282
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Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy
2018 · Shuyi Wang, Machender R. Kandadi, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 53
Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation
2017 · Jun Ren, Lifang Yang, et al. · Aging Cell · 126
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BMI trajectory groups in veterans of the Iraq and Afghanistan wars
2011 · Patricia H. Rosenberger, Yuming Ning, et al. · Preventive Medicine · 38
Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction
2010 · Qun Li, Subat Turdi, et al. · Toxicology Letters · 43
UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK
2009 · Qun Li, Ji Li, et al. · American Journal of Physiology-Endocrinology and Metabolism · 29
CARDIAC-SPECIFIC OVEREXPRESSION OF INSULIN-LIKE GROWTH FACTOR I (IGF-1) RESCUES lIPOPOLYSACCHARIDE-INDUCED CARDIAC DYSFUNCTION AND ACTIVATION OF STRESS SIGNALING IN MURINE CARDIOMYOCYTES
2009 · Peng Zhao, Subat Turdi, et al. · Shock · 46
Retracted: Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up‐regulation contribute to the onset of diabetic cardiomyopathy
2008 · Heng Ma, Shi‐Yan Li, et al. · Journal of Cellular and Molecular Medicine · 155
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Deficiency of Insulin-Like Growth Factor 1 Reduces Sensitivity to Aging-Associated Cardiomyocyte Dysfunction
2008 · Qun Li, Asli F. Ceylan-Isik, et al. · Rejuvenation Research · 67
IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction
2008 · Jun Ren, Jinhong Duan, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 63
Insulin-Like Growth Factor I Deficiency Prolongs Survival and Antagonizes Paraquat–Induced Cardiomyocyte Dysfunction: Role of Oxidative Stress
2007 · Qun Li, Xiaoping Yang, et al. · Rejuvenation Research · 44
Influence of cardiac‐specific overexpression of insulin‐like growth factor 1 on lifespan and aging‐associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression
2007 · Qun Li, Jun Ren · Aging Cell · 69
Cardiac overexpression of antioxidant catalase attenuates aging-induced cardiomyocyte relaxation dysfunction
2006 · Jun Ren, Qun Li, et al. · Mechanisms of Ageing and Development · 74
Cardiac‐specific Overexpression of Catalase Prolongs Lifespan and Attenuates Ageing‐induced Cardiomyocyte Contractile Dysfunction and Protein Damage
2006 · Shan Wu, Qun Li, et al. · Clinical and Experimental Pharmacology and Physiology · 52
Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage
2006 · Qun Li, Shan Wu, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 103
Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch
2006 · S.-Y. Li, X. Yang, et al. · Diabetologia · 188
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Metallothionein prolongs survival and antagonizes senescence‐associated cardiomyocyte diastolic dysfunction: role of oxidative stress
2006 · Xiaoping Yang, Thomas A. Doser, et al. · The FASEB Journal · 150
Metallothionein antagonizes aging‐induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt
2006 · Cindy X. Fang, Thomas A. Doser, et al. · Aging Cell · 46
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Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function
2005 · Shi-Yan Li, Cindy X Fang, et al. · Journal of Endocrinology · 32
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Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration
2005 · Feng Dong, Xiaochun Zhang, et al. · Clinical Science · 177
Maternal nutrient restriction during early to mid gestation up-regulates cardiac insulin-like growth factor (IGF) receptors associated with enlarged ventricular size in fetal sheep
2005 · Feng Dong, Stephen P. Ford, et al. · Growth Hormone & IGF Research · 59
Endothelin‐1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin‐1
2005 · Feng Dong, Xiaochun Zhang, et al. · British Journal of Pharmacology · 211
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Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification
2005 · Shi‐Yan Li, Min Du, et al. · Aging Cell · 124
Possible Involvement of NADPH Oxidase and JNK in Homocysteine-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells
2005 · Feng Dong, Xiaochun Zhang, et al. · Cardiovascular Toxicology · 50